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Nighttime reflux is more damaging to the esophagus because gravity is no longer helping keep acid in the stomach, and the protective swallowing reflex is reduced during sleep

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Non-canonical STAT3 signaling via GRIM19 (gene associated with retinoid-interferon-induced mortality)- dependent import of STAT3 into the mitochondria increases the activity of complexes I and II of the electron transport chain and OXPHOS, leading to TKI therapeutic resistance [70]